alexa Functions of galectin-3 and its role in fibrotic diseases.


Clinical & Medical Biochemistry

Author(s): Li LC, Li J, Gao J, Li LC, Li J, Gao J

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Abstract Fibrotic diseases occur in a variety of organs and lead to continuous organ injury, function decline, and even failure. Currently effective treatment options are limited. Galectin-3 (Gal-3) is a pleiotropic lectin that plays an important role in cell proliferation, adhesion, differentiation, angiogenesis, and apoptosis. Accumulating evidence indicates that Gal-3 activates a variety of profibrotic factors, promotes fibroblast proliferation and transformation, and mediates collagen production. Recent studies have defined key roles for Gal-3 in fibrogenesis in diverse organ systems, including liver, kidney, lung, and myocardial. To help set the stage for future research, we review recent advances about the role played by Gal-3 in fibrotic diseases. Herein we discuss the potential profibrotic role of Gal-3, inhibition of which may represent a promising therapeutic strategy against tissue fibrosis. Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics. This article was published in J Pharmacol Exp Ther and referenced in Clinical & Medical Biochemistry

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