alexa Functions of HIV envelope glycans.


HIV: Current Research

Author(s): Fenouillet E, Gluckman JC, Jones IM, Fenouillet E, Gluckman JC, Jones IM

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Abstract The unusually highly glycosylated state of the major envelope glycoprotein (gp160) of the human immunodeficiency virus has offered a challenge to both glycobiologists and virologists. What is the functional significance of such a mass of glycans and how might they be manipulated to disadvantage virus pathogenesis? Some answers to each of these questions have already been obtained: N-linked glycans are necessary for the creation, but not the maintenance, of a bioactive conformation, and drug-induced alteration of the glycosylation pattern can lead to impaired virus infectivity. As a model for studying glycan function and as a target for antiviral therapy, gp160 represents a unique candidate. This article was published in Trends Biochem Sci and referenced in HIV: Current Research

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