alexa Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis.


Journal of Immunobiology

Author(s): Pawelek JM, Chakraborty AK, Pawelek JM, Chakraborty AK, Pawelek JM, Chakraborty AK, Pawelek JM, Chakraborty AK

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Abstract The causes of metastasis remain elusive despite vast information on cancer cells. We posit that cancer cell fusion with macrophages or other migratory bone marrow-derived cells (BMDCs) provides an explanation. BMDC-tumour hybrids have been detected in numerous animal models and recently in human cancer. Molecular studies indicate that gene expression in such hybrids reflects a metastatic phenotype. Should BMDC-tumour fusion be found to underlie invasion and metastasis in human cancer, new approaches for therapy would surely follow. This article was published in Nat Rev Cancer and referenced in Journal of Immunobiology

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