alexa GC Quantification of Residual hexyl methane sulfonate in Dabigatran etexilate mesylate
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): NBalaji, VRSivaraman, P Neeraja

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A simple and a quantitative Gas chromatography ( GC) method with oncolumn injection technique have been developed for the q uantification of trace level hexyl methane sulfonate in Dabigatran etexilate mesylate . The chromatographic separation is achieved on DB - Wax , (30 m x 0. 53 mm x 1.0 μm) capillary column and the instrument employed for the method development and validation was Agilent6890N GC equipped with flame ionization detector ( FID) . GC run time was 2 5 min employing programmed temperature with split less mode on column injection. In the developed method the limit of detection ( LOD) of Hexyl methane sulfonate is 0. 2 5 ppm and the limit of quantificat ion (LOQ) of Hexyl methane sulfonate is 0.75 ppm . The method is validated for specificity, linearity, accuracy and precision . The developed method can be very well employed and can be used in the quality control laboratories to monitor and control the trace level of hexyl methane sulfonate i n Active pharmaceutical ingredients (API)

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This article was published in IOSR Journal of Applied Chemistry and referenced in Journal of Chromatography & Separation Techniques

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