alexa GDIs: central regulatory molecules in Rho GTPase activation.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): DerMardirossian C, Bokoch GM

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Abstract The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and GTPase-activating proteins, to effector targets and to membranes where such effectors reside. We discuss here our current understanding of how Rho GTPase-GDI complexes are regulated by various proteins, lipids and enzymes that exert GDI displacement activity. We propose that phosphorylation mediated by diverse kinases might provide a means of controlling and coordinating Rho GTPase activation. This article was published in Trends Cell Biol and referenced in Journal of Cell Science & Therapy

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