alexa Gene targeting in stem cells from individuals with osteogenesis imperfecta.
Orthopaedics

Orthopaedics

Orthopedic & Muscular System: Current Research

Author(s): Chamberlain JR, Schwarze U, Wang PR, Hirata RK, Hankenson KD,

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Abstract Adult stem cells offer the potential to treat many diseases through a combination of ex vivo genetic manipulation and autologous transplantation. Mesenchymal stem cells (MSCs, also referred to as marrow stromal cells) are adult stem cells that can be isolated as proliferating, adherent cells from bones. MSCs can differentiate into multiple cell types present in several tissues, including bone, fat, cartilage, and muscle, making them ideal candidates for a variety of cell-based therapies. Here, we have used adeno-associated virus vectors to disrupt dominant-negative mutant COL1A1 collagen genes in MSCs from individuals with the brittle bone disorder osteogenesis imperfecta, demonstrating successful gene targeting in adult human stem cells. This article was published in Science and referenced in Orthopedic & Muscular System: Current Research

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