alexa Gene therapy clinical trials worldwide to 2007--an update.


Clinical Pediatrics: Open Access

Author(s): Edelstein ML, Abedi MR, Wixon J, Edelstein ML, Abedi MR, Wixon J

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Abstract To date, over 1340 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. In 1997 we set up a database to bring together global information on gene therapy clinical trials as comprehensively as possible. The data are compiled and regularly updated from official agency sources, published literature, conference presentations and posters and from information kindly provided by investigators or trial sponsors themselves. This review updates our descriptive overview of the data in 2004 1, presenting our analysis of the clinical trials that, to the best of our knowledge, have been or are being performed worldwide. As of July 30 2007, we have stored entries on 1309 trials in 28 countries. We have analyzed the geographical distribution of trials, the disease indications (or other reasons) for trials, the proportions to which different vector types are used, and which genes have been transferred. Details of the analyses presented, and our interactive, searchable database can be found on The Journal of Gene Medicine Gene Therapy Clinical Trials Worldwide website at: Copyright 2007 John Wiley & Sons, Ltd. This article was published in J Gene Med and referenced in Clinical Pediatrics: Open Access

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