Author(s): Khokhar N, Gill ML, Malik GJ
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Abstract OBJECTIVE: To determine the prevalence of hepatitis C virus (HCV) and hepatitis B virus (HBV) infection by detection of anti-HCV and hepatitis B surface antigen (HbsAg) in general population of Pakistan. DESIGN: Observational. PLACE AND DURATION OF STUDY: Community clinic of Shifa International Hospital, Islamabad, from January 1998 to June 2004. MATERIALS AND METHODS: Sera of healthy adult individuals who presented for medical evaluation as a pre-employment criteria in the Gulf region were examined for presence of hepatitis B surface antigen and anti-HCV antibody. Alanine aminotransferase levels were also determined. RESULTS: A total of 47,538 individuals were examined. Out of these, 2528 (5.31\%) were positive for anti-HCV and 1221 (2.56\%) individuals had positive HBsAg. Hepatitis B surface antigen and anti-HCV both were found in 92 (0.19\%) individuals. Mean age of subjects, positive for HCV antibody was 44 years and 40.5 years for HBV. Ninety-four percent individuals were males and 6\% were females. Alanine aminotransferase (ALT) was normal in 56 \% of subjects with positive HCV and 84\% of individuals with HBV. CONCLUSION: This study which evaluated predominantly a healthy male population, showed a high seroprevalence of anti-HCV and average seroprevalence of hepatitis B virus infection. A large majority of these patients was young and had normal ALT.
This article was published in J Coll Physicians Surg Pak
and referenced in Journal of Bioequivalence & Bioavailability