Author(s): Taylor CJ, Peacock S, Chaudhry AN, Bradley JA, Bolton EM
Abstract Share this page
Abstract The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93\% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals. Copyright © 2012 Elsevier Inc. All rights reserved.
This article was published in Cell Stem Cell
and referenced in Journal of Stem Cell Research & Therapy