alexa Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Taylor CJ, Peacock S, Chaudhry AN, Bradley JA, Bolton EM

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Abstract The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93\% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals. Copyright © 2012 Elsevier Inc. All rights reserved. This article was published in Cell Stem Cell and referenced in Journal of Stem Cell Research & Therapy

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