alexa [Genetic analyses of rheumatoid arthritis].
Healthcare

Healthcare

Health Care : Current Reviews

Author(s): Yamamoto K

Abstract Share this page

Abstract The etiology of rheumatoid arthritis (RA) is unknown and genetic information is important for understanding the mechanisms of the disorder. In order to identify diseases-associated genes, genome wide association study (GWAS) has been performed. Through GWAS, many RA associated genes have been reported. Several genes are related to T cell differentiation, signaling in the immune cells, innate immunity and TNF signaling. Some of these polymorphisms are shared by several autoimmune diseases. On the other hands, it is important to know that there are ethnic differences in these autoimmune related genes. We reported functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with RA. We also identified an RA associated polymorphism in the promoter region of FCRL3, a member of the Fc receptor-like family. Through these studies, we believe that we could obtain further insights into the disease mechanisms, develop novel therapies and make personalized medicine possible based on the individual's genetics.
This article was published in Nihon Rinsho and referenced in Health Care : Current Reviews

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords