alexa Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic.


Tropical Medicine & Surgery

Author(s): Lim JK, Louie CY, Glaser C, Jean C, Johnson B,

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Abstract West Nile virus (WNV) causes disease in approximately 20\% of infected humans. We previously reported that homozygosity for CCR5Delta32, a nonfunctional variant of chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts from California and Illinois. An increase in CCR5-deficient subjects was found in both (for California, odds ratio [OR], 4.2 [95\% confidence interval {CI}, 1.5-11.9] [P= .004]; for Illinois, OR, 3.1 [95\% CI, 0.9-11.2] [P= .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95\% CI, 2.1-8.3 [P= .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States. This article was published in J Infect Dis and referenced in Tropical Medicine & Surgery

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