alexa Genetic lesions in diffuse large B-cell lymphomas.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular Biomarkers & Diagnosis

Author(s): Testoni M, Zucca E, Young KH, Bertoni F

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Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults, accounting for 35\%-40\% of all cases. The combination of the anti-CD20 monoclonal antibody rituximab with anthracycline-based combination chemotherapy (R-CHOP, rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone) lead to complete remission in most and can cure more than half of patients with DLBCL. The diversity in clinical presentation, as well as the pathologic and biologic heterogeneity, suggests that DLBCL comprises several disease entities that might ultimately benefit from different therapeutic approaches. In this review, we summarize the current literature focusing on the genetic lesions identified in DLBCL. © The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected]
This article was published in Ann Oncol and referenced in Journal of Molecular Biomarkers & Diagnosis

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