Author(s): Altshuler D, Daly MJ, Lander ES, Altshuler D, Daly MJ, Lander ES
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Abstract Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.
This article was published in Science
and referenced in Molecular Biology: Open Access