alexa Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City
Medicine

Medicine

Journal of Traditional Medicine & Clinical Naturopathy

Author(s): Romieu, J J SienraMonge, M RamrezAguilar, H MorenoMacas, N I ReyesRuiz

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Background: We recently reported that antioxidant supplementation with vitamins C and E mitigated ozone related decline in forced expiratory flow (FEF25–75) in 158 asthmatic children in an area with high ozone exposure in Mexico City. Methods: A study was undertaken to determine whether deletion of glutathione S-transferase M1 (GSTM1 null genotype), a gene involved in response to oxidative stress, influences ozone related decline in FEF25–75 and the benefit of antioxidant supplementation. Results:GSTM1 null children receiving placebo had significant ozone related decrements in FEF25–75 (percentage change per 50 ppb of ozone 2.9 (95% CI −5.2 to −0.6), p = 0.01); GSTM1 positive children did not. Conversely, the effect of antioxidants was stronger in children with the GSTM1 null genotype. Conclusions: Asthmatic children with a genetic deficiency of GSTM1 may be more susceptible to the deleterious effects of ozone on the small airways and might derive greater benefit from antioxidant supplementation.

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This article was published in Thorax and referenced in Journal of Traditional Medicine & Clinical Naturopathy

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