Author(s): Wang Y, Qu Y, Song W
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Abstract AIM: Ths study aims to explore the relationship between COX-2 gene polymorphism and the hereditary susceptibility or endoomeyriosis and adenomyosis. MATERIALS AND METHODS: Gene polymorphism in COX-2 gene was genotyped in 170 cases of endometriosis, 150 cases of adenomyosis, and 240 matched non-endometriosis and non-adenomyosis controls. RESULTS: Genotypic frequencies of GG, AG, and AA in COX-2 locus in endometriosis and adenomyosis were 16.5\%, 51.2\%, 32.4\% and 16.0\%, 49.3\%, 34.7\%, respectively. They were both significantly different from those in the control group (24.6\%, 53.3\%, and 22.1\%) (p < 0.05). An allele frequency in endometriosis and adenomyosis were significantly higher than that in the control group. The risk of endometriosis or adenomyosis for those carrying two A alleles were 2.19 and 2.41 times to non-A genotype. CONCLUSION: Genetic variation of G to A at -1195 locus in the promoter region of COX-2 gene increases the risk of endometriosis and adenomyosis, and the genetic susceptibility of these two diseases are similar.
This article was published in Clin Exp Obstet Gynecol
and referenced in Advancements in Genetic Engineering