alexa Genetics of autistic disorders: review and clinical implications.
Neurology

Neurology

Autism-Open Access

Author(s): Freitag CM, Staal W, Klauck SM, Duketis E, Waltes R

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Abstract Twin and family studies in autistic disorders (AD) have elucidated a high heritability of AD. In this literature review, we will present an overview on molecular genetic studies in AD and highlight the most recent findings of an increased rate of copy number variations in AD. An extensive literature search in the PubMed database was performed to obtain English published articles on genetic findings in autism. Results of linkage, (genome wide) association and cytogenetic studies are presented, and putative aetiopathological pathways are discussed. Implications of the different genetic findings for genetic counselling and genetic testing at present will be described. The article ends with a prospectus on future directions.
This article was published in Eur Child Adolesc Psychiatry and referenced in Autism-Open Access

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