Author(s): Ramos A, Edreira A, Vizoso A, Betancourt J, Lpez M
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A fluid extract of Calendula officinalis L. displayed genotoxic properties when assayed for mitotic segregation in the heterozygous diploid D-30 of Aspergillusnidulans. The extract of Calendula exhibited dose-dependent toxicity and genotoxicity (both mitotic crossing-over and chromosome malsegregation being observed) to Aspergillus in the range of five plate concentrations from 0.1 to 1.0 mg of solids/ml assayed. Mutagenicity testing with the Salmonella/microsome assay in strains TA 1535, TA 1537, TA 98 and TA 100 was negative in a plate incorporation protocol, with concentrations ranging from 50 to 5000 μg/plate (±S9). The mouse bone marrow micronucleus test, where the extract was dosed orally up to 1 g/kg for 2 days, was also negative.
This article was published in Journal of Ethnopharmacology
and referenced in Journal of Carcinogenesis & Mutagenesis