alexa Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays.
Genetics

Genetics

Molecular Biology: Open Access

Author(s): Matsuzaki H, Dong S, Loi H, Di X, Liu G, , Matsuzaki H, Dong S, Loi H, Di X, Liu G,

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Abstract We present a genotyping method for simultaneously scoring 116,204 SNPs using oligonucleotide arrays. At call rates >99\%, reproducibility is >99.97\% and accuracy, as measured by inheritance in trios and concordance with the HapMap Project, is >99.7\%. Average intermarker distance is 23.6 kb, and 92\% of the genome is within 100 kb of a SNP marker. Average heterozygosity is 0.30, with 105,511 SNPs having minor allele frequencies >5\%. This article was published in Nat Methods and referenced in Molecular Biology: Open Access

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