alexa Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.
Genetics

Genetics

Advancements in Genetic Engineering

Author(s): Schwartzberg PL, Goff SP, Robertson EJ

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Abstract A substitution mutation has been introduced into the c-abl locus of murine embryonic stem cells by homologous recombination between exogenously added DNA and the endogenous gene, and these cells have been used to generate chimeric mice. It is shown that the c-abl mutation was transmitted to progeny by several male chimeras. This work demonstrates the feasibility of germ-line transmission of a mutation introduced into a nonselectable autosomal gene by homologous recombination.
This article was published in Science and referenced in Advancements in Genetic Engineering

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