alexa Ginger (Zingiber officinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: mechanism of action.
Nutrition

Nutrition

Journal of Nutrition & Food Sciences

Author(s): Jagetia G, Baliga M, Venkatesh P

Abstract Share this page

Abstract The radioprotective effect of hydroalcoholic extract of ginger rhizome (Zingiber officinale; ZOE) was studied in mice administered 250 mg/kg ZOE orally using oral gavage once daily for 5 consecutive days before exposure to 6, 7, 8, 9, 10, or 11 Gy of gamma-radiation. The animals were monitored daily up to 30 days postirradiation for the development of symptoms of radiation sickness and mortality. Pretreatment of mice with ZOE reduced the severity of symptoms of radiation sickness and mortality at all the exposure doses and also increased the number of survivors in a ZOE + irradiation group compared to the concurrent double-distilled water + irradiation group. The ZOE treatment protected mice against gastrointestinal-related deaths as well as bone-marrow-related deaths. The dose-reduction factor was found to be 1.2. The administration of ZOE after exposure to irradiation was not effective, as no survivors lasted up to 30 days postirradiation. Reducing the administration schedule to 3 days or increasing the schedule to 7 days was not as effective compared to a 5 consecutive days' schedule. The irradiation of animals resulted in a dose-dependent elevation in the lipid peroxidation, while depletion in the glutathione (GSH) contents occurred on day 31 postirradiation. Treatment of mice with ZOE before irradiation caused a significant depletion in lipid peroxidation followed by a significant elevation in GSH concentration in the livers of mice at 31 days postirradiation. The mechanism of action of ZOE was determined by evaluating its free-radical scavenging capability. Ginger was found to scavenge *OH, O2*- and ABTS*+ radicals in a dose-dependent manner in vitro. The drug was nontoxic up to a dose of 1500 mg/kg body weight, the highest drug dose that could be tested for acute toxicity. Copyright Mary Ann Liebert, Inc. This article was published in Cancer Biother Radiopharm and referenced in Journal of Nutrition & Food Sciences

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • Food Processing & Technology
    October 02-04, 2017 London, UK
  • Public Health, Epidemiology & Nutrition
    November 13-14, 2017 Osaka, Japan
  • Food Processing & Technology
    December 05-07, 2016 San Antonio, USA
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords