alexa Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis.
Pathology

Pathology

Journal of Clinical & Experimental Pathology

Author(s): Zhu D, Wu L, Li CR, Wang XW, Ma YJ,

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Abstract Ginsenoside Rg1 is a major active ingredient of Panax notoginseng radix which has demonstrated a number of pharmacological actions including a cardioprotective effect in vivo. This study investigated the protective effect and mechanism of ginsenoside Rg1 in cardiomyocytes hypoxia/reoxygenation (H/R) model. Pretreatment with ginsenoside Rg1 (60-120 microM) reduced lactate dehydrogenase release and increased cell viability in a dose-dependent manner. Fluorescence analysis demonstrated ginsenoside Rg1 reduced intracellular ROS and suppressed the intracellular [Ca(2+)] level. Cell lysate detected an increase of T-SOD, CAT, and GSH levels. The myocardial protection of ginsenoside Rg1 during H/R is partially due to its antioxidative effect and intracellular calcium homeostasis. (c) 2009 Wiley-Liss, Inc. This article was published in J Cell Biochem and referenced in Journal of Clinical & Experimental Pathology

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