Author(s): SerranoMartn X, Payares G, MendozaLen A
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Abstract Glibenclamide reduced the rate of lesion growth in BALB/c mice infected with Leishmania (Leishmania) mexicana, the effect was dose dependent, and the highest dose proved more effective than glucantime. Cross-resistance to glucantime was found in animals infected with a glibenclamide-resistant line, but combined therapy reduced lesion progression even in the glibenclamide-resistant strain.
This article was published in Antimicrob Agents Chemother
and referenced in Journal of Molecular and Genetic Medicine