alexa Glucocorticoid exposure in utero: new model for adult hypertension.
Cardiology

Cardiology

Journal of Clinical & Experimental Cardiology

Author(s): Benediktsson R, Lindsay RS, Noble J, Seckl JR, Edwards CR

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Abstract Hypertension is strongly predicted by the combination of low birthweight and a large placenta. This association could be due to increased fetal exposure to maternal glucocorticoids. Fetal protection is normally effected by placental 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD), which converts physiological glucocorticoids to inactive products. We found that rat placental 11 beta-OHSD activity correlated positively with term fetal weight and negatively with placental weight. Offspring of rats treated during pregnancy with dexamethasone (which is not metabolised by 11 beta-OHSD) had lower birthweights and higher blood pressure when adult than did offspring of control rats. Increased fetal glucocorticoid exposure secondary to attenuated placental 11 beta-OHSD activity may link low birthweight and high placental weight with hypertension.
This article was published in Lancet and referenced in Journal of Clinical & Experimental Cardiology

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