alexa Glucocorticoid treatment in acute lung injury and acute respiratory distress syndrome.
Pulmonology

Pulmonology

Journal of Pulmonary & Respiratory Medicine

Author(s): Marik PE, Meduri GU, Rocco PR, Annane D

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Abstract Experimental and clinical evidence show a strong association between dysregulated systemic inflammation and progression of acute respiratory distress syndrome (ARDS). This article reviews eight controlled studies evaluating corticosteroid treatment initiated before day 14 of ARDS. Available data provide a consistent strong level of evidence for improving outcomes. Treatment was also associated with a markedly reduced risk of death. This low-cost highly effective therapy is well-known, and has a low-risk profile when secondary prevention measures are implemented. The authors recommend prolonged methylprednisolone at 1 mg/kg/d initially in early ARDS, increasing to 2 mg/kg/d after 7 to 9 days of no improvement. Copyright © 2011 Elsevier Inc. All rights reserved. This article was published in Crit Care Clin and referenced in Journal of Pulmonary & Respiratory Medicine

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