alexa Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Wyllie AH

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Abstract In near-physiological concentrations, glucocorticoid hormones cause the death of several types of normal and neoplastic lymphoid cell, but the mechanisms involved are unknown. One of the earliest structural changes in the dying cell is widespread chromatin condensation, of the type characteristic of apoptosis, the mode of death frequently observed where cell deletion seems to be 'programmed'. It is shown here that this morphological change is closely associated with excision of nucleosome chains from nuclear chromatin, apparently through activation of an intracellular, but non-lysosomal, endonuclease.
This article was published in Nature and referenced in Journal of Nanomedicine & Nanotechnology

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