alexa Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling.
Neurology

Neurology

Neurochemistry & Neuropharmacology

Author(s): CornellBell AH, Finkbeiner SM, Cooper MS, Smith SJ, CornellBell AH, Finkbeiner SM, Cooper MS, Smith SJ, CornellBell AH, Finkbeiner SM, Cooper MS, CornellBell AH, Smith SJ, Finkbeiner SM, Cooper MS, Smith SJ

Abstract Share this page

Abstract The finding that astrocytes possess glutamate-sensitive ion channels hinted at a previously unrecognized signaling role for these cells. Now it is reported that cultured hippocampal astrocytes can respond to glutamate with a prompt and oscillatory elevation of cytoplasmic free calcium, visible through use of the fluorescent calcium indicator fluo-3. Two types of glutamate receptor--one preferring quisqualate and releasing calcium from intracellular stores and the other preferring kainate and promoting surface-membrane calcium influx--appear to be involved. Moreover, glutamate-induced increases in cytoplasmic free calcium frequently propagate as waves within the cytoplasm of individual astrocytes and between adjacent astrocytes in confluent cultures. These propagating waves of calcium suggest that networks of astrocytes may constitute a long-range signaling system within the brain.
This article was published in Science and referenced in Neurochemistry & Neuropharmacology

Relevant Expert PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords