alexa Glutamate-evoked redox state alterations are involved in tissue transglutaminase upregulation in primary astrocyte cultures.


Medicinal chemistry

Author(s): Campisi A, Caccamo D, Li Volti G, Curr M, Parisi G,

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Abstract The aim of this study was to evaluate the involvement of oxidative stress in glutamate-evoked transglutaminase (TGase) upregulation in astrocyte cultures (14 DIV). A 24 h exposure to glutamate caused a dose-dependent depletion of glutathione intracellular content and increased the ROS production in cell cultures. These effects were receptor-mediated, as demonstrated by inhibition with GYKI 52466. The pre-incubation with glutathione ethyl ester or cysteamine recovered oxidative status and was effective in significantly reducing glutamate-increased tissue TGase. These data suggest that tissue TGase upregulation may be part of a biochemical response to oxidative stress induced by a prolonged exposure of astrocyte cultures to glutamate. This article was published in FEBS Lett and referenced in Medicinal chemistry

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