Author(s): Unger RH, Scherer PE, Unger RH, Scherer PE
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Abstract Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin. Published by Elsevier Ltd.
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This article was published in Trends Endocrinol Metab
and referenced in Journal of Diabetes & Metabolism