alexa Glycemic control and long-acting insulin analog utilization in patients with type 2 diabetes.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Heintjes EM, Thomsen TL, Penningvan Beest FJ, Christensen TE, Herings RM, Heintjes EM, Thomsen TL, Penningvan Beest FJ, Christensen TE, Herings RM

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Abstract INTRODUCTION: The objective was to compare glycemic control, insulin utilization, and body weight in patients with type 2 diabetes (T2D) initiated on insulin detemir (IDet) or insulin glargine (IGlar) in a real-life setting in the Netherlands. METHODS: Insulin-naïve patients with T2D, starting treatment with IDet or IGlar between January 1, 2004 and June 30, 2008, were selected from the PHARMO data network. Glycemic control (hemoglobin A1c [HbA1c]), target rates (HbA1c <7\%), daily insulin dose, and weight gain were analyzed comparing IDet and IGlar for patients with available HbA1c levels both at baseline and at 1-year follow-up. Analysis of all eligible patients (AEP) and a subgroup of patients without treatment changes (WOTC) in the follow-up period were adjusted for patient characteristics, propensity scores, and baseline HbA1c. RESULTS: A total of 127 IDet users and 292 IGlar users were included in the WOTC analyses. The mean HbA1c dropped from 8.4\%-8.6\% at baseline to 7.4\% after 1 year. Patients at HbA1c goal increased from 9\% at baseline to 32\% for IDet and 11\% to 35\% for IGlar, which was not significantly different (OR 0.75, 95\% CI 0.46, 1.24). Weight gain (n=90) was less among IDet users (+0.4 kg) than among IGlar users (+1.1 kg), albeit not significant. The AEP analysis (252 IDet + 468 IGlar users) showed similar results with 33\%-36\% at goal (OR 0.81, 95\% CI 0.57, 1.16), and median daily insulin doses of 25 IU/day (P=0.70). CONCLUSION: There was no significant difference between users of IDet and IGlar with respect to glycemic control and insulin dose in a real-life setting. The low proportion of patients on target at baseline may indicate that insulin therapy is initiated too late. Moreover, the observation that one-third of the patients reached HbA1c target at follow-up may indicate that basal insulin analogs are not titrated intensively enough. This article was published in Adv Ther and referenced in Journal of AIDS & Clinical Research

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