alexa GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Medicine

Medicine

Family Medicine & Medical Science Research

Author(s): Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve FalckYtter

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Failure to consider the quality of evidence can lead to misguided recommendations; hormone replacement therapy for post-menopausal women provides an instructive example High quality evidence that an intervention’s desirable effects are clearly greater than its undesirable effects, or are clearly not, warrants a strong recommendation Uncertainty about the trade-offs (because of low quality evidence or because the desirable and undesirable effects are closely balanced) warrants a weak recommendation Guidelines should inform clinicians what the quality of the underlying evidence is and whether recommendations are strong or weak The Grading of Recommendations Assessment, Development and Evaluation (GRADE ) approach provides a system for rating quality of evidence and strength of recommendations that is explicit, comprehensive, transparent, and pragmatic and is increasingly being adopted by organisations worldwide

This article was published in BMJ and referenced in Family Medicine & Medical Science Research

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