Author(s): IkingKonert C, Ostendorf B, Foede M, FischerBetz R, Jung G,
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Abstract Recombinant human granulocyte colony-stimulating factor (rhuG-CSF) is frequently given to patients with leukopenia or neutropenia caused by various underlying diseases. The treatment with rhuG-CSF is apparently safe, although cutaneous vasculitis and flares in patients with autoimmune diseases are described. We describe 2 patients with histologically proven antineutrophil cytoplasmic antibody-associated systemic vasculitis with disease flares after administration of rhuG-CSF, given to improve collection of stem cells prior to autologous stem cell transplantation.
This article was published in J Rheumatol
and referenced in Journal of Clinical & Experimental Dermatology Research