alexa Granulomatous slack skin disease: a review, in comparison with mycosis fungoides.


Journal of Clinical & Experimental Dermatology Research

Author(s): Shah A, Safaya A

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Abstract Granulomatous slack skin (GSS) is a rare cutaneous disorder characterized by the evolution of circumscribed erythematous loose skin masses, especially in the body folds, and histologically by a loss of elastic fibers and granulomatous T-cell infiltrates. This disease is often associated with preceding or successive lymphoproliferative malignancies, especially Mycosis Fungoides (MF) and Hodgkin's Disease (HD). Whether Granulomatous Slack Skin Disease is a benign disorder, an unusual host reaction or a precursor of malignant lymphoma or an indolent Cutaneous T-cell Lymphoma (CTCL) in itself, is still a controversy. This article reviews its literature on the etiology, clinical findings, and treatment of Granulomatous Slack Skin Disease. It also concentrates on its association with Hodgkin's disease and its comparison with Mycosis Fungoides and Sezary Syndrome. © 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology. This article was published in J Eur Acad Dermatol Venereol and referenced in Journal of Clinical & Experimental Dermatology Research

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