alexa Green Spectrophotometric Method for the Quantitative Analysis of Vancomycin in Pharmaceuticals and Comparison with HPLC
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Alvino Rodrigues Jnior, Marta M D C Vila, Matthieu Tubino

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A spectrophotometric method for the determination of vancomycin base, (VCM), and vancomycin hydrochloride, (HVCM), based on the reaction with copper (II) ions, is presented. The obtained detection limit is about 4.5×10−5 mol L−1. The working analytical range falls between 1.0×10−3 mol L−1 and 1.0×10−2 mol L−1. Recovery studies in presence of excipients were performed. The recovery results were compared with HPLC. For HVCM the proposed method presented similar recovery to that of HPLC, 100.4% vs. 100.2%, but better precision, 1.9% vs. 6.1%. In the VCM case the recovery is quite better, 100.5% vs. 89.6%, with a little smaller precision, 2.1% vs. 1.3%.

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This article was published in Analytical Letters and referenced in Journal of Chromatography & Separation Techniques

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