alexa Green tea EGCG suppresses T cell proliferation through impairment of IL-2 IL-2 receptor signaling.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Wu D, Guo Z, Ren Z, Guo W, Meydani SN

Abstract Share this page

Abstract Studies have suggested a benefit of consuming green tea in promoting general health and reducing the risk of certain diseases. However, little is known about the effect of green tea on immune function. In this study we determined the effect of epigallocatechin-3-gallate (EGCG), the major active component of tea, on proliferation of spleen cells isolated from C57BL mice. Results showed that T cell proliferation was inhibited by EGCG at physiologically relevant concentrations of 2.5 to 10 microM. EGCG at these concentrations did not induce cytotoxicity or apoptosis. Oxidative stress is not likely to be responsible for the EGCG-induced suppression of T cell proliferation because H(2)O(2) generation was not significantly different between the cultures supplemented with 1 to 10 microM EGCG and control and catalase did not prevent this EGCG-induced inhibition. Further mechanistic studies showed that EGCG dose dependently inhibited T cell division and cell cycle progression. EGCG supplementation resulted in lower IL-2 receptor expression and higher IL-2 accumulation, suggesting an impeded IL-2/IL-2 receptor signaling. These results indicate that EGCG supplementation may be beneficial to those with abnormally excessive T cell function such as autoimmune and inflammatory disorders, but caution should be taken when it is administered at high doses to those with compromised T cell function. This article was published in Free Radic Biol Med and referenced in Journal of Cytology & Histology

Relevant Expert PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

so[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords