alexa Guinea pig serum L-asparaginase: purification, and immunological relationship to liver L-asparaginase and serum L-asparaginases in other mammals.


Journal of Microbial & Biochemical Technology

Author(s): Zhang N, Clarke F, Di Trapani G, Keough D, Beacham I, Zhang N, Clarke F, Di Trapani G, Keough D, Beacham I

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Abstract L-asparaginase, an enzyme used in the treatment of acute lymphocytic leukemia, is found in the serum of only a few mammalian groups, including the guinea pig and its close relatives in the superfamily Cavioidea. This report describes the purification and characterization of L-asparaginase from guinea pig serum. Antiserum against the purified enzyme cross-reacted with sera from other Cavioidean species but not with mouse serum. Relatively weak cross-reaction with unpurified L-asparaginase in guinea pig liver indicates a significant degree of evolutionary divergence.
This article was published in Comp Biochem Physiol B Biochem Mol Biol and referenced in Journal of Microbial & Biochemical Technology

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