Author(s): MatevekeKuona P, Bwakura MF, Dzangare J, Pazvakavambwa I
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Abstract OBJECTIVE: To determine the prevalence of peripheral haematological abnormalities in children receiving cotrimoxazole prophylaxis. DESIGN: An outpatient hospital based cross sectional study. SETTING: The study was conducted at two tertiary peadiatric HIV clinics that offer comprehensive care to children living with HIV. SUBJECTS: 202 HIV infected, antiretroviral therapy naive children aged between 3 months and 12 years who were receiving cotrimoxazole prophylaxis for at least 1 month with more than95\% adherence to prophylaxis were included. MAIN OUTCOME MEASURES: Haematological abnormalities on full blood count and peripheral film. RESULTS: The prevalence of anaemia was 62\% with normocytic normochromic anaemia being the most frequent type (45\%). The commonest red blood cell abnormality was rouleaux formation on the peripheral film. Monocytosis occurred in 62\%, leucopaenia in 39\%, eosinophilia in 34\%, neutropaenia in 18\% and lymphopaenia in 10\% of the children. CONCLUSION: This study showed a high prevalence ofhaematological abnormalities in HIV infected children on cotrimoxazole prophylaxis. It emphasizes the need for evaluation for anaemia and its management in children on cotrimoxazole prophylaxis.
This article was published in Cent Afr J Med
and referenced in Journal of Microbial & Biochemical Technology