alexa Handling calcium signaling: Arabidopsis CaMs and CMLs.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Proteomics & Bioinformatics

Author(s): McCormack E, Tsai YC, Braam J

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Abstract The Arabidopsis genome harbors seven calmodulin (CAM) and 50 CAM-like (CML) genes that encode potential calcium sensors. The CAMs encode only four protein isoforms. Selective pressure to maintain multiple CAMs indicates nonredundancy. Sequence divergence, even in the EF hand calcium-binding motif, exists among the CMLs and, therefore, divergent functions are likely to have evolved. Expression data recently available from Massively Parallel Signature Sequencing and Genevestigator compilation of microarrays are reviewed. The seven Arabidopsis CAMs are highly and relatively uniformly expressed. Differential expression is evident among the distinct CMLs over developmental stages, in various organs and in response to many different stimuli. In spite of the potential importance in mediating plant calcium signaling, the physiological functions of the Arabidopsis CaMs and CMLs remain largely unknown. This article was published in Trends Plant Sci and referenced in Journal of Proteomics & Bioinformatics

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