alexa Handling of computational in vitro in vivo correlation problems by Microsoft Excel: IV. Generalized matrix analysis of linear compartment systems.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Langenbucher F

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Abstract A linear system comprising n compartments is completely defined by the rate constants between any of the compartments and the initial condition in which compartment(s) the drug is present at the beginning. The generalized solution is the time profiles of drug amount in each compartment, described by polyexponential equations. Based on standard matrix operations, an Excel worksheet computes the rate constants and the coefficients, finally the full time profiles for a specified range of time values. This article was published in Eur J Pharm Biopharm and referenced in Pharmaceutica Analytica Acta

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