alexa Harmonic behavior of trehalose-coated carbon-monoxy-myoglobin at high temperature.
Chemistry

Chemistry

Journal of Physical Chemistry & Biophysics

Author(s): Cordone L, Ferrand M, Vitrano E, Zaccai G

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Abstract Embedding biostructures in saccharide glasses protects them against extreme dehydration and/or exposure to very high temperature. Among the saccharides, trehalose appears to be the most effective bioprotectant. In this paper we report on the low-frequency dynamics of carbon monoxy myoglobin in an extremely dry trehalose glass measured by neutron spectroscopy. Under these conditions, the mean square displacements and the density of state function are those of a harmonic solid, up to room temperature, in contrast to D2O-hydrated myoglobin, in which a dynamical transition to a nonharmonic regime has been observed at approximately 180 K (Doster et al., 1989. Nature. 337:754-756). The protective effect of trehalose is correlated, therefore, with a trapping of the protein in a harmonic potential, even at relatively high temperature.
This article was published in Biophys J and referenced in Journal of Physical Chemistry & Biophysics

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