alexa he prognostic significance of p16 overexpression in oropharyngeal squamous cell carcinoma: implications for treatment strategies and future clinical studies.


Journal of Carcinogenesis & Mutagenesis

Author(s): Langendijk JA, Psyrri A

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In many studies investigating the prognostic significance of p16-overexpression, the investigators assumed a significant correlation between HPV-positivity determined by in situ hybridisation and p16 overexpression. In situ hybridisation with an HPV16 probe has a sensitivity of one to two copies of integrated HPV DNA. When the virus is integrated, the HPV hybridisation signal is seen as punctate nuclear staining. Some investigators use HPV in situ hybridisation to determine the integration status and, presumably, the transcriptional activity of HPV in oropharyngeal tumours. They interpret punctate staining in tumours as a marker of integrated transcriptionally active virus.

This article was published in Ann Oncol. and referenced in Journal of Carcinogenesis & Mutagenesis

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