alexa Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists.


Journal of Integrative Oncology

Author(s): Metcalfe C, de Sauvage FJ

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Abstract Acquired resistance to targeted therapies threatens the value of these otherwise very promising agents. The recent description of resistance to the Hedgehog pathway inhibitor vismodegib (GDC-0449) in a medulloblastoma patient who had a dramatic initial response has spurred efforts to understand potential mechanisms of drug resistance. Elucidating these mechanisms will play a significant role in informing strategies to overcome this meaningful limitation. This article was published in Cancer Res and referenced in Journal of Integrative Oncology

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