Author(s): Sarrazin S, Lamanna WC, Esko JD
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Abstract Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and coreceptors. Although few in number, heparan sulfate proteoglycans have profound effects at the cellular, tissue, and organismal level.
This article was published in Cold Spring Harb Perspect Biol
and referenced in Reconstructive Surgery & Anaplastology