Author(s): To WW, Cheung W, Mok KM
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Abstract OBJECTIVE: To determine whether chronic hepatitis B surface antigen (HBsAg) carrier status is associated with an increased incidence of gestational hypertension. METHODS: A retrospective analysis of all deliveries in a regional obstetric unit over a 4-year period using a comprehensive obstetric database. RESULTS: The data of 13,792 patients were analysed, of which 1340 (9.71\%) were chronic HBsAg carriers. Contrary to our hypothesis, the overall incidence of gestational hypertension was significantly lower in the HBsAg positive group (2.01\%) as compared to the negative group (3.58\%) (P < 0.01, odds ratio (OR) 0.55, 95\% confidence interval (CI) 0.37-0.81). When comparing the incidence of severe preeclampsia, the difference remained significant (0.22 and 0.79\%, respectively, P < 0.05, OR 0.28, 95\% CI 0.08-0.88). There was otherwise no difference in the incidence of other major obstetric complications between the HBsAg positive and negative groups. CONCLUSION: The findings presented did not support a positive association between HbsAg carrier status and gestational hypertension. The data from the present study, and re-evaluation of similar published data, in fact suggest the contrary observation of a lower than normal incidence of gestational hypertension in HbsAg positive mothers.
This article was published in Aust N Z J Obstet Gynaecol
and referenced in Journal of Addiction Research & Therapy