alexa Hepatitis B virus blood screening: unfinished agendas.
Infectious Diseases

Infectious Diseases

Journal of Infectious Diseases & Therapy

Author(s): Comanor L, Holland P

Abstract Share this page

Abstract The risk of transfusion-transmitted hepatitis B virus (TTHBV) has been steadily reduced through the use of volunteer donors, enhanced donor questioning, and increasingly sensitive hepatitis B surface antigen (HBsAg) tests. In a few countries, screening by antibody to hepatitis B core antigen (anti-HBc) and/or hepatitis B virus (HBV) nucleic acid amplification tests (NAT) has also been introduced. Nevertheless, the risk of TTHBV in most countries is higher than the risk of either human immunodeficiency virus-1 (HIV-1) or hepatitis C virus (HCV). HBV screening practices vary both in terms of the markers screened and the tests employed, and are often dependent on a country's healthcare resources. Anti-HBc screening could be employed as an additional safety feature in HBV low-prevalence countries, but would lead to the rejection of a high percentage of otherwise acceptable donations in HBV moderate- and high-prevalence countries. It has been argued that only individual-donor HBV NAT testing would substantially reduce the risk of TTHBV beyond that achieved by the most sensitive HBsAg tests. However, studies from countries with low, moderate and high HBV prevalence have demonstrated NAT yield from window period- and late stage HBV-infected donors, even using minipool testing following the most sensitive HBsAg tests. This article was published in Vox Sang and referenced in Journal of Infectious Diseases & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords