alexa Hepatitis C virus infection and coronary artery disease risk: a systematic review of the literature.


Journal of Gastrointestinal & Digestive System

Author(s): Wong RJ, Kanwal F, Younossi ZM, Ahmed A

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Abstract BACKGROUND AND AIMS: While hepatitis C virus (HCV) infection has been implicated in increasing the risk of coronary artery disease (CAD), conflicting reports exist regarding this association. We performed a systematic review to further investigate this association. METHODS: We conducted a PubMed search of original research articles from January 1, 1995 to June 30, 2013 to identify case-control and cohort studies evaluating the association between HCV and CAD using keyword terms ["hepatitis c" or "HCV"] and ["coronary artery disease" or "heart disease" or "atherosclerosis."] The primary CAD-related endpoints included myocardial infarction, congestive heart failure, need for coronary artery bypass grafting, or transluminal percutaneous coronary angioplasty. Binary outcomes are reported as odds ratios (OR) with 95 \% confidence interval (CI). RESULTS: We identified five studies (four cohort studies and one case-control study) that met our inclusion criteria. A significant association between HCV and CAD was demonstrated in one cohort study (adjusted HR 1.27; 95 \% CI 1.22-1.31). One cohort study demonstrated a decreased risk of CAD associated with HCV (adjusted OR 0.74; 95 \% CI 0.71-0.76). The remaining studies did not find a significant association between HCV and risk of CAD. CONCLUSIONS: The current systematic review demonstrates that the association between HCV and CAD remains unclear. We need more large, long-term cohort studies with clear definitions of patient population and endpoints to better ascertain the association between HCV and CAD. This article was published in Dig Dis Sci and referenced in Journal of Gastrointestinal & Digestive System

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