Author(s): Ayoola EA, Gadour MO
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Abstract BACKGROUND AND AIM: To estimate the risk of hepatocellular carcinoma (HCC) in non-alcoholic patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, 118 patients who were admitted to a regional hospital in Saudi Arabia were compared with 118 age- and sex-matched healthy individuals. RESULTS: The prevalence of HBsAg in HCC patients (67\%; 95\% confidence interval (CI): 57.7-75.3) was significantly higher than the rate (6.7\%; 95\%CI: 3.0-12.9) in the controls (OR: 28.4; 95\%CI: 12.6-63.9; P < 0.001). There was a high risk of HCC in the presence of HBsAg alone (OR: 34.3; 95\%CI: 14.8-79.1, P < 0.001) and anti-HCV alone (OR: 12.2; 95\%CI: 3.2-47.2; P < 0.001). Although HBV and HCV were independent risk factors in the development of HCC, there was no interactive relationship between the two viruses. Dual infections occurred in only 3.4\% and were associated with only a moderate increase in the risk of HCC (OR: 14.6; 95\%CI: 1.57-135.9). In 24.6\% of the cases no virus was identified as the etiologic factor. CONCLUSION: Hepatitis B virus constitutes a major risk factor and HCV contributes a less significant role in the development of HCC. The ongoing program of HBV vaccination may significantly decrease the prevalence of HBV-associated HCC in this population.
This article was published in J Gastroenterol Hepatol
and referenced in Epidemiology: Open Access