alexa Herpes simplex virus type-1 glycoprotein D gene: nucleotide sequence and expression in Escherichia coli.
Immunology

Immunology

Journal of Vaccines & Vaccination

Author(s): Watson RJ, Weis JH, Salstrom JS, Enquist LW

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Abstract The protein coding region of the herpes simplex virus type-1 glycoprotein D (gD) gene was mapped, and the nucleotide sequence was determined. The predicted amino acid sequence of the gD polypeptide was found to contain a number of features in common with other virus glycoproteins. Insertion of this protein coding region into a bacterial expressor plasmid enabled synthesis in Escherichia coli of an immunoreactive gD-related polypeptide. The potential of this system for preparation of a type-common herpes simplex virus vaccine is discussed.
This article was published in Science and referenced in Journal of Vaccines & Vaccination

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