alexa HFE, the MHC and hemochromatosis: paradigm for an extended function for MHC class I.
Oncology

Oncology

Journal of Cancer Science & Therapy

Author(s): Cardoso CS, de Sousa M

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Abstract HFE was discovered as the hereditary hemochromatosis (HH) gene. It is located on chromosome 6 (6p21.3), 4Mb telomeric to the HLA-A locus, and its product has a structure similar to MHC class I molecules. HFE encodes two frequent mutations: C282Y and H63D. One of these (C282Y) is present in a large proportion of Caucasian HH patients. HFE has a tissue distribution compatible with a role in iron absorption (intestine), recycling (macrophages) and transport to the fetus (placenta).
This article was published in Tissue Antigens and referenced in Journal of Cancer Science & Therapy

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