alexa Hide and seek: Identification and confirmation of small molecule protein targets.
Oncology

Oncology

Journal of Cancer Science & Therapy

Author(s): Ursu A, Waldmann H

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Abstract Target identification and confirmation for small molecules is often the rate limiting step in drug discovery. A robust method to identify proteins addressed by small molecules is affinity chromatography using chemical probes. These usually consist of the compound of interest equipped with a linker molecule and a proper tag. Recently, methods emerged that allow the identification of protein targets without prior functionalization of the small molecule of interest. The digest offers an update on the newest developments in the area of target identification with special focus on confirmation techniques. Copyright © 2015 Elsevier Ltd. All rights reserved. This article was published in Bioorg Med Chem Lett and referenced in Journal of Cancer Science & Therapy

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