Author(s): De Jong CA, Roozen HG, van Rossum LG, Krabbe PF, Kerkhof AJ
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Abstract In this multi-center, naturalistic study, the effectiveness of naltrexone maintenance combined with the Community Reinforcement Approach (CRA) was investigated in detoxified, opioid-dependent patients (N=272). Patients were recruited from methadone maintenance programs. With intention-to-treat analysis, 10 months of treatment yielded abstinence rates of 28\% and 32\% at 10 and 16 months after detoxification. The cumulative abstinence rate at 16 months was 24\%. Quality of life, craving, general psychopathology, use of other psychoactive substances, and addiction severity of the abstinent group significantly improved when compared to the relapsed group. This abstinence-oriented approach appears to be a feasible goal, and remains an important option next to long-term methadone maintenance in the management of opioid dependence.
This article was published in Am J Addict
and referenced in Journal of Addiction Research & Therapy